Huntington's Disease

Uncovering circuits, cells, and molecular pathways underlying the pathogenesis of Huntington’s disease, with the goal of finding therapeutics targets.

Basal Ganglia Circuitry

Studying basal ganglia circuitry to shed light on normal behavior, psychiatric disorders, and addiction.

MORF Reporter Mice

MORF (MOnonucleotide Repeat Frameshift) is a powerful Cre-dependent sparse cell labeling methodology developed by the Yang lab to reveal the brainwide, intricate morphology or hundreds to thousands of genetically-defined neurons or glial cells.

Latest Lab News and Highlights

 
The Yang lab's latest Neuron publication, "Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures"
The Yang lab's latest Neuron publication, "Uninterrupted CAG repeat drives striatum-selective transcriptinopathy and nuclear pathogenesis in human Huntingtin BAC mice"
The Yang lab's latest Neuron publication, "Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice."
[go to Publications for more info]
 

Click to go to MORF-BRAIN.com

 
Former Yang lab member, Dr. Michelle Gray, profiled as a "Scientist to Watch" in The Scientist
MORF highlighted by the BRAIN Initiative Director in the Multi-Council Working Group Meeting (August 2020)
Dr. William Yang named as the Terry Semel Chair in Alzheimer's Disease Research and Treatment
The Yang lab's recent Neuron paper featured in Alzforum
The Yang lab wins BRAIN Initiative's "Show Us Your Brain!" video contest.
Yang lab's MORF research highlighted in the NIH Director's Blog
[go to Media for more Info]
 
The Yang lab's latest Neuron publication, "Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures"
Click here to learn more.
 
Congratulations to the BRAIN Initiative Cell Census Network (BICCN) for their 17 articles in Nature and 10 articles in other Nature-published Journals which encompass the collaborative effort to integrate a variety of large-scale data sets to map and define brain cell types. The Yang Lab and MORF reporter mice actively contributed to the following 4 publications:
Cellular anatomy of the mouse primary motor cortex (PMID: 34616071)
Morphological diversity of single neurons in molecularly defined cell types (PMID: 34616072)
The mouse cortico–basal ganglia–thalamic network (PMID: 34616074)
A multimodal cell census and atlas of the mammalian primary motor cortex (PMID: 34616075)
[Click to go to BICCN Collection]