Huntington's Disease

Uncovering circuits, cells, and molecular pathways underlying the pathogenesis of Huntington’s disease, with the goal of finding therapeutics targets.

Basal Ganglia Circuitry

Studying basal ganglia circuitry to shed light on normal behavior, psychiatric disorders, and addiction.

MORF Reporter Mice

MORF (MOnonucleotide Repeat Frameshift) is a powerful Cre-dependent sparse cell labeling methodology developed by the Yang lab to reveal the brainwide, intricate morphology or hundreds to thousands of genetically-defined neurons or glial cells.

Latest Lab News and Highlights

 

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The Yang lab's latest Cell publication, "Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice" featured in UCLA Health Newsroom

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Former Yang lab member, Dr. Michelle Gray, profiled as a "Scientist to Watch" in The Scientist

MORF highlighted by the BRAIN Initiative Director in the Multi-Council Working Group Meeting (August 2020)

Dr. William Yang named as the Terry Semel Chair in Alzheimer's Disease Research and Treatment

The Yang lab's recent Neuron paper featured in Alzforum

The Yang lab wins BRAIN Initiative's "Show Us Your Brain!" video contest

Yang lab's MORF research highlighted in the NIH Director's Blog

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Congratulations to the BRAIN Initiative Cell Census Network (BICCN) for their 17 articles in Nature and 10 articles in other Nature-published Journals which encompass the collaborative effort to integrate a variety of large-scale data sets to map and define brain cell types. The Yang Lab and MORF reporter mice actively contributed to the following 4 publications:

Cellular anatomy of the mouse primary motor cortex (PMID: 34616071)

Morphological diversity of single neurons in molecularly defined cell types (PMID: 34616072)

The mouse cortico–basal ganglia–thalamic network (PMID: 34616074)

A multimodal cell census and atlas of the mammalian primary motor cortex (PMID: 34616075)

Click to go to BICCN Collection.

 

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