THE X. WILLIAM YANG RESEARCH GROUP @ UCLA

 

 
 
  • Gu X, Andre VM, Cepeda C, Li SH, Li XJ, Levine MS, Yang XW.Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease. Mol Neurodegener. 2007 Apr 30;2:8.(Abstract | Full text | PDF)
  • Mary Kay Lobo, Stanislav L Karsten, Michelle Gray, Daniel H Geschwind & X William Yang. FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nature Neuroscience, Published online: 19 February 2006
    (Abstract | Full text | PDF (716K)  | MIAME)
  • Gu X, Li C, Wei W, Lo V, Gong S, Li S, Iwasato T, Itohara S, Li X, Mody I, Heintz N, Yang XW. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin critically contribute to cortical pathogenesis in vivo. Neuron 46; 433-444, 2005(link)
  • Yang XW, Gong S. An Overview on Generation of BAC Transgenic Mice for Neuroscience Research. Current Protocols in Neuorscience (Link).
  • Gong S, Yang XW. Modification of Bacterial Artificial Chromosomes (BACs) and Preparation of Intact BAC DNA for Generation of Transgenic Mice. Current Protocols in Neuorscience (Link).
  • Gong S, Yang XW, Li CJ, Heintz N. Highly efficient modification of Bacterial Artificial Chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication. Genome Res. 12:1992-8, 2002. (PubMed)
  • Misulovin Z, Yang XW, Yu W, Heintz N, Merfre E. A rapid method for targeted modification and screening of recombinant Bacterial Artificial Chromosome. J. Immuno. Methods 257: 99-105, 2002.(PubMed)
  • Yang XW, Wynder C, Doughty ML, Heintz N. BAC mediated gene-dosage analysis reveals a role for Zipro1(Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Nature Genetics 22: 327-335, 1999.(PubMed)
  • Yang XW, Model P, Heintz N. Homologous recombination based modification in E.Coli and germline transmission in transgenic mice of an 131kb Bacterial Artificial Chromosome (BAC). Nature Biotechnology 15: 859-865, 1997.(PubMed)
  • Yang XW, Zhong R, Heintz N. Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor Ru49. Development 122: 555-566, 1996.(PubMed)
  • Baserga SJ, Gilmore-Hebert M, Yang XW. Distinct molecular signals for nuclear import of the nucleolar snRNA, U3. Genes & Development 6: 1120-1130, 1992.(PubMed)
  • Baserga SJ, Yang XW, Steitz JA. An intact box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs. EMBO J. 10: 2645-2651, 1991.(PubMed)
  • Baserga SJ, Yang XW, Steitz JA. Three pseudogenes for human U13 snRNA belong to class III. Gene 1991, 107: 347-348.(PubMed)

 

Molecular Genetics Approach
Huntington's Disease
Parkinson's Disease
Basal Ganglia Biology
BAC Transgenesis

 

 
Yang Lab 2005 @ UCLA