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This
project is aimed to test candidate genes and genetic pathways which may
supress the toxic effects of mutant huntingtin in the brain. Our laboratory
is applying high-speed BAC transgenesis to generate mice that express
candidate suppressor genes in the brain. We will breed these HD suppressor
mice with the BACHD mice to test their efficacy in preventing mutant huntingtin
toxicity in vivo. Identification of effective genetic suppressors may
provide novel mechanistic insights and therapeutic targets for HD.
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